QU Pre-Matriculation Program: Environmental Factors and Lupus
Lupus is a complex autoimmune disease affecting millions worldwide. Its cause is unknown, but genetics and environment contribute. Although the specific environmental agent responsible for triggering lupus has not been identified, researchers continue to explore various possibilities. Among the most commonly cited triggers are ultraviolet light (UVA and UVB), infections such as the Epstein-Barr virus, and exposure to silica dust in agricultural or industrial settings. In this blog, we explore Courtney McGinnis' research on environmental triggers and lupus symptoms.
About Dr. Courtney McGinnis
Dr. Courtney McGinnis, a Biology and Medical Sciences Professor at Quinnipiac University, specializes in multiplexed CRISPR-Cas9 systems. With a PhD in Physiology and Neurobiology from the University of Connecticut and experience at Yale University, her expertise is recognized with the Quinnipiac University 2017 Excellence in Teaching Award. She focuses on Anatomy and Physiology, as well as Physiological Models of Human Disease.
Ultraviolet Rays and Medication
UV rays from the sun and fluorescent light bulbs can trigger lupus flares. Some medications, like sulfa drugs and sun-sensitizing tetracycline drugs, increase sensitivity to sunlight. Lupus patients must be cautious and protect themselves from excessive sun exposure.
Stress
Emotional stress and physical exhaustion have been linked to lupus flares. Events like divorce, illness, death in the family, and other life complications can significantly impact a person's well-being. It is essential for individuals with lupus to prioritize stress management techniques and seek support when needed to minimize the potential for flare-ups.
Silica Exposure
Silica, Earth's most abundant mineral, is linked to lupus. Jobs with silica exposure, like mining and glass production, raise the risk. Over 2.3 million Americans face crystalline silica exposure, emphasizing the need for occupational safety measures to safeguard workers.
Pesticides
Farmers and agricultural laborers who are exposed to pesticides in their work environment face a higher risk of developing lupus. Moreover, the long-term or frequent use of at-home pesticides, particularly insecticides, has been associated with an increased risk of lupus, particularly in postmenopausal women. Reducing exposure to pesticides and opting for natural alternatives can help mitigate this risk.
Viruses and Infections
Certain viral infections, including the Epstein-Barr virus (mono) and parvo-B19, have been implicated in advancing the progression of lupus. It is crucial for individuals with lupus to prioritize their overall health, practice good hygiene, and take necessary precautions to minimize the risk of infections.
Household Chemicals
The relationship between household chemicals and lupus is still not entirely clear. However, some individuals with lupus report experiencing flares when exposed to certain cleaning products. To minimize potential risks, it is advisable to replace harsh cleaning products with natural alternatives like baking soda, vinegar, and lemon.
Cigarette Smoking
Cigarette smoking has been associated with an increased risk of lupus. Individuals with lupus are advised to quit smoking to mitigate the potential exacerbation of their symptoms.
Oral Contraceptives
Regarding oral contraceptives, studies have yielded mixed findings. While some research indicates that oral contraceptives do not increase the risk of flare among women with stable systemic lupus erythematosus (SLE), longer-term use of contraceptives and higher doses of ethinyl estradiol may be associated with an increased risk of incident lupus.
Understanding environmental triggers in lupus is crucial for patients. Although more research is needed, minimizing exposure to potential triggers can enhance their quality of life. Protective strategies help manage symptoms and reduce flare-ups.